The poisonous dose of barbiturates may differ substantially. Generally, an oral dose of 1 gram of most barbiturates provides major poisoning in an Grownup.pentobarbital decreases amounts of elvitegravir/cobicistat/emtricitabine/tenofovir DF by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. May bring on lack of virologic rea